Resveratrol as an enhancer of apoptosis in cancer: a mechanistic review

M Ashrafizadeh, S Taeb… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
… , that p53 has a key role in the anti-cancer activity of resveratrol [54]. … Induction of sirtuin-1
signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor

[HTML][HTML] Resveratrol's anti-cancer effects through the modulation of tumor glucose metabolism

A Brockmueller, S Sameri, A Liskova, K Zhai… - Cancers, 2021 - mdpi.com
… fruits and vegetables exhibit promising therapeutic potential … Finally, resveratrol-induced
ER-stress leads to apoptosis of … Resveratrol upregulates sirtuin 1 (Sirt1); Sirt1-dependent …

[HTML][HTML] Mechanism of resveratrol-induced programmed cell death and new drug discovery against cancer: A Review

JY Jang, E Im, ND Kim - International journal of molecular sciences, 2022 - mdpi.com
… apples, has been reported to exhibit a wide range of biological … of resveratrol and increase
its anticancer activity are … to induce the formation of the death-inducing signaling complex (…

[PDF][PDF] Protective effect of resveratrol on knee osteoarthritis and its molecular mechanisms: a recent review in preclinical and clinical trials

S Yang, M Sun, X Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
… that RES can exhibit a biphasic dose-effect. In ethanol-induced cell death models, RES is …
pathway, RES can also modulate multiple other signaling pathways that mediate apoptosis

A pharmacological review on SIRT 1 and SIRT 2 proteins, activators, and inhibitors: Call for further research

M Nandave, R Acharjee, K Bhaduri, J Upadhyay… - International Journal of …, 2023 - Elsevier
… suggests that resveratrol-generated apoptosis is caused by … It induced the cell cycle arrest
of glioma cells and apoptosis … the anticancer effect of JGB1741 on three different tumor cell

[HTML][HTML] Effect of SIRT1 activators and inhibitors on CD44+/CD133+‑enriched non‑small cell lung cancer cells

Z Eroglu, C Erdem, G Oktem… - Molecular …, 2020 - spandidos-publications.com
… the mRNA and protein expression of sirtuin 1 (SIRT1) and p53 … to have an antitumor effect
by inducing cell apoptosis via the … that resveratrol is an important agent for inducing apoptosis

[HTML][HTML] A proteasome-dependent inhibition of SIRT-1 by the resveratrol analogue 4, 4′-dihydroxy-trans-stilbene

V Livraghi, L Mazza, F Chiappori, M Cardano… - Journal of Traditional …, 2024 - Elsevier
… RSV exerts its effects is by activating Sirtuin 1 (SIRT1). In fact… of action underlying the
antiproliferative e antitumor activity of … The strongest and significant reduction of SIRT1 induced by …

[HTML][HTML] … of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis

WC Lin, YL Chiu, KL Kuo, PM Chow… - American Journal of …, 2023 - ncbi.nlm.nih.gov
… (DUBs) exhibit increased expression levels in tumor cells. … anti-tumor effect of DUBs
inhibitors are yet to be explored. … showed that PR-619 induced cytotoxicity, cell cycle arrest, ER …

[HTML][HTML] Beneficial Oxidative Stress-Related trans-Resveratrol Effects in the Treatment and Prevention of Breast Cancer

A Quarta, A Gaballo, B Pradhan, S Patra, M Jena… - Applied Sciences, 2021 - mdpi.com
… protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-… Resveratrol can induce
cancer cell death through the … mechanism underlying the anticancer effect of resveratrol in both …

[HTML][HTML] The Effects and Mechanisms of Sennoside A on Inducing Cytotoxicity, Apoptosis, and Inhibiting Metastasis in Human Chondrosarcoma Cells

J Le, H Ji, P Pi, K Chen, X Gu, Y Ma, Y Fu… - Evidence-Based …, 2022 - hindawi.com
… defined the biological functions and signaling pathways of … in the anticancer effect of SA
on chondrosarcoma cells, we … e tumor cells undergoing EMT typically exhibit some changes …